منابع مشابه
Macrophage deactivation by interleukin 10
Recombinant mouse interleukin 10 (IL-10) was exceedingly potent at suppressing the ability of mouse peritoneal macrophages (m phi) to release tumor necrosis factor alpha (TNF-alpha). The IC50 of IL-10 for the suppression of TNF-alpha release induced by 0.5 microgram/ml lipopolysaccharide was 0.04 +/- 0.03 U/ml, with as little as 1 U/ml suppressing TNF-alpha production by a factor of 21.4 +/- 2....
متن کاملMacrophage Deactivation by Interleukln 10
Recombinant mouse interleukin 10 (IL-10) was exceedingly potent at suppressing the ability of mouse peritoneal macrophages (mOb) to release tumor necrosis factor a (TNF-o~). The ICs0 of IL-10 for the suppression of TNF-ol release induced by 0.5 #g/ml lipopolysaccharide was 0.04 _+ 0.03 U/ml, with as little as 1 U/ml suppressing TNF-ot production by a factor of 21.4 + 2.5. At 10 U/ml, II.-10 mar...
متن کاملAlveolar macrophage deactivation in murine septic peritonitis: role of interleukin 10.
Sepsis predisposes the host to a number of infectious sequelae, particularly the development of nosocomial pneumonia. Mechanisms by which sepsis results in impairment of lung antibacterial host defense have not been well defined. Alveolar macrophages (AM) represent important immune effector cells of the lung airspace. In this study, we examined the effects of cecal ligation and puncture (CLP) o...
متن کاملInterleukin-10 inhibits macrophage-induced glomerular injury.
The ability of interleukin-10 (IL-10) to inhibit macrophage recruitment, activation, and proliferation in vivo was studied in a macrophage-mediated, but T cell-independent, passive anti-glomerular basement membrane antibody-induced model of glomerulonephritis (GN) in rats. Treatment with recombinant murine IL-10 resulted in dose-dependent reductions in proteinuria (high dose: 16 +/- 1 mg/24 h; ...
متن کاملEvidence for the Involvement of Interleukin 10 Differential Deactivation of Murine Peritoneal Macrophages by Prostaglandin E
Among other effects, prostaglandins (PG) of the E series are known to inhibit several acute and chronic inflammatory conditions in vivo and proinflammatory cytokine production by activated macrophages in culture. The research presented here demonstrates that the inhibitory effect of PGE2 on tumor necrosis factor oe (TNF-oL) and interleukin 6 (IL-6) production by lipopolysaccharide (LPS)-stimula...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1991
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.174.6.1549